The Structure of Brevistin
ثبت نشده
چکیده
Acid hydrolysis revealed the constituent amino acids of brevistin as follows: aspartic acid (D-form 2, L-form 1), L-threonine (1), glycine (1), sum of L-valine and L-isoleucine (1), [L-phenylalanine (1), L-tryptophan (1), and 2, 4-diaminobutyric acid (D-form 1, L-form 1). The constituent fatty acid was elucidated to be anteisononanoic acid by gas chromatography-mass spectrometry. A lactone linkage was proved between phenylalanine and the hydroxy group of threonine. Opening the lactone ring with dilute alkali afforded brevistinic acid. Deacylation with an enzyme preparation, Polymyxin Acylase, gave deacyl brevistinic acid. Cleavage reaction with N-bromosuccinimide, sequential analysis by EDMAN degradation and some additional evidences clarified the total structure of brevistin.
منابع مشابه
Isolation of brevistin, a new peptide antibiotic. Studies on antibiotics from the genus Bacillus. IX.
A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol...
متن کاملRedesigning Bazaar Physical Structure According to its Dealing Culture Structure- Case Study: Arab Bazaar in Ahvaz City
Redesigning Bazaar Physical Structure According to its Dealing Culture Structure Case Study: Arab Bazaar in Ahvaz City The Bazaar physical structure is formed from the arrangement syntax of division units, Interfaces, joints and boundaries to each other and the Arabic Bazaar also follows this example. This structure is the result of arrangement syntax of division units with linear pattern a...
متن کاملA critical review on structure-soil-structure interaction
The purpose of this paper is to review computational methods in structure-soil-structure interaction. As a result of globalization, buildings are located close to each other. This issue happens especially in big cities, making the study of structure-soil-structure interaction as an essential part of structural design process. The effect of soil medium, on which the building structure stands, es...
متن کاملThe Role of Government in Shaping the Spatial Structure of Isfahan City during the Safavid period
The spatial structure of cities has been one of the influential elements in the development of cities in different periods.In the cities of Iran,the spatial structure of cities is sometimes organic and during the lifetime of cities ,based on the requirements of the times,such as socio_social needs and their religious-religious ideology,and in many cases,this structure is based on programs and g...
متن کاملHalf-metallic properties of KP compound in a bulk and (001) surface of rock-salt structure: A b-initio study
Given the many applications of half-metals in the spintronics devices, we investigated the half-metallic properties of the KP compound in rock-salt (RS) and cesium chloride (CsCl) structural phases by using density functional theory. The results indicated that the KP compound as the half-metal in the RS structure, in contrast to the CsCl structure, due to the small lattice constant and failure ...
متن کامل